BY AGENCY REPORTER
DENMARK has ceased giving the Oxford-AstraZeneca Covid vaccine amid concerns about rare cases of blood clots, the first European country to do so fully.
The move is expected to delay the country’s vaccination programme by several weeks.
Drug watchdog the European Medicines Agency last week announced a possible link with clots but said the risk of dying of Covid-19 was much greater.
Several European countries had previously briefly suspended the jab.
Most have now resumed vaccinations with AstraZeneca, but often with limits to older age groups.
On Tuesday, the US, Canada and the European Union paused the Johnson & Johnson vaccine for similar reasons over clotting.
South Africa has also paused its use, despite the Johnson & Johnson being its preferred vaccine because of its effectiveness against the South African variant.
For both AstraZeneca and Johnson & Johnson, the blood clot side effects are extremely rare.
Blood clot is ‘very rare AstraZeneca side effect’
What you need to know about vaccine safety
The EU’s vaccine roll-out has been criticised by the World Health Organization (WHO) for being too slow, and there are concerns this latest delay could throw it into further turmoil.
Both vaccines work by a similar method, known as adenoviral vectors.
Why is Denmark stopping the AZ vaccine?
Danish officials said that all 2.4 million doses of the AstraZeneca vaccine would be withdrawn until further notice.
The Danish Health Authority said studies had shown a higher than expected frequency of blood clots following doses, affecting about one in 40,000 people.
It comes after two cases of thrombosis in Denmark were linked to vaccinations, AFP reported. One of the cases, in a 60-year-old woman, was fatal.
Director General Soren Brostrom said it had been a “difficult decision” but Denmark had other vaccines available and the epidemic there was currently under control.
“The upcoming target groups for vaccination are less likely to become severely ill from Covid-19,” he said. “We must weigh this against the fact that we now have a known risk of severe adverse effects from vaccination with AstraZeneca, even if the risk in absolute terms is slight.”
However, the authority said it could not rule out using it again at another time.
During the press conference the head of Denmark’s Medicines Agency, Tanja Erichsen, fainted and was taken to hospital as a precaution. The agency later tweeted that she had recovered.
Almost one million people in Denmark have been vaccinated, with approximately 150,000 of them receiving the AstraZeneca jab. The Pfizer/BioNTech and Moderna vaccines are also in use.
How do adenovirus vaccines work?
Adenoviruses are found in humans and other animals. Scientists use a modified version of one of these adenoviruses, known as a vector, to deliver important instructions to cells, according to the US Centers for Disease Control (CDC).
They work by entering cells and using the cell’s machinery to produce a harmless piece of the virus that causes Covid-19, known as a spike protein. The cell then recognises that the spike protein does not belong there and this triggers the immune system to fight back against what it thinks is an infection.
This process allows our bodies to learn how to protect us against Covid-19, according to the CDC.
Regulators are now investigating whether an unusual immune response to the adenovirus vaccines is causing the rare but severe incidences of blood clotting.
An official from the US Food and Drug Administration told Reuters it was “plainly obvious” that the cases of blood clots linked to the Johnson & Johnson vaccine were “very similar” to those linked to the AstraZeneca vaccine.
The US paused rollout of the Johnson & Johnson vaccine after six women under 50 developed rare blood clots after getting the shot. In the UK 30 people had developed unusual blood clots and seven of them had died after getting the Oxford-AstraZeneca vaccine, out of a total of 18 million vaccinated.
What are other countries doing?
Some European countries have limited the use of adenovirus vaccines to older people, who have been less affected by the rare blood clotting condition.
After the Danish announcement, France said it viewed the AstraZeneca vaccine as an “essential tool”.
“It is important that this vaccine continue to be deployed. It is a vaccine that is safe and works,” a French government spokesman said.
– BBC
